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West Virginia's pharmacy association issued an order that only 30 tablets of the drug can be prescribed at a time. But since President Trump touted hydroxychloroquine as a 'game-changer' last week, demand and prescriptions have surged. A University of Utah drug shortage monitoring program reports shortages already for hydroxychloroquine tablets made by four companies - Amneal, Mylan, Major and Teva.
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Tablets made by Zydus, Concordia which makes the brand name drug, Plaquenil , Sandoz and Prasco are still available. Doctors are only meant to prescribe it some coronavirus patients, largely for the purpose of collecting data on the drug's effects in combination with the common antibiotic, azithromycin.
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But health officials and the FDA have repeatedly cautioned that the drugs are unproven. However, Dr Anthony Fauci of the White House's coronavirus task force has repeatedly warned that the drug is not proven and should not be seen as a magic bullet. The views expressed in the contents above are those of our users and do not necessarily reflect the views of MailOnline.
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Today's headlines Most Read Meet the doctors and nurses on the coronavirus frontline: Medical staff risking their lives show red marks NHS doctors will die unless they are given adequate personal protection to fight the coronavirus crisis, the Woman, 21, with no pre-existing conditions dies from coronavirus, family reveal as they pay tribute EXCLUSIVE - 'Two patients died before my eyes': Healthy tech boss, 40, fought coronavirus in intensive care Coronavirus crisis could cause a loneliness epidemic in older adults: Study shows cutting off overs from The US is not slated for inclusion.
Hydroxychloroquine, the form of the drug that will now be used 'compassionately' in the US, was given to 24 out of 36 trial participants. Half of them cleared the infection entirely, according to an early announcement of the results on Wednesday. The FDA's permission for doctors to prescribe it is on an experimental, 'compassionate use' basis only. But already pharmacists have reported that they are running out of the pills, with some warning that doctors are prescribing chloroquine to themselves and hoarding the drugs.
One thing can be said for certain: Chloroquine has stirred excitement and controversy over conflicting findings and guidance from various countries, studies and experts. South Korea's COVID task force went so far as to say that studies on the drug demonstrated it had 'certain curative effect' and 'fairly good efficacy. Patients treated with hydroxychloroquine improved more quickly and broke their fevers earlier than those who did not receive the drug. The drug is also included in China's treatment guidelines for COVID - described there as 'chloroquine phosphate - for use in patients between 18 and It is one of five antivirals suggested in the 7th edition of China's treatment plan , which also cautions the drug should not be given to patients with heart disease, as it has potential cardiac side effects.
After promising test results in petri dish studies, some Chinese scientists came to believe that hydroxychloroquine was powerful against viruses in general, and for COVID in particular. Nearly 55, Americans have coronavirus, fueling desperation for an effective treatment. Chloroquine is being tested in clinical trials, but is not yet proven to work. Developed during World War II and approved by the the Food and Drug Administration FDA in , hydroxychloroquine cured about half of the 24 patients who received the drug there were 36 included in a French clinical trial published yesterday.
It was the first clinical trial of the drug for treating COVID after Chinese scientists found that it killed the virus in lab experiments, according to a study published in the Clinical Infectious Diseases Journal on March 9. US patients with 'mild' coronavirus disease are currently being recruited for a trial of hydroxychloroquine sold under the brand name Plaquenil , to be tested against the effects of another pair of antivirals, posted to clincaltrials. Hydroxychloroquine is also used to treat some forms of arthritis in some instances. When it was released half-a-century ago, the malaria drug was hailed for having milder side effects than its predecessor.
If it's used long-term, the treatment can irreversibly damage the retina, as signalled by trouble focusing, streaks of flashes of light in patients' vision and eye swelling or color changes. The drug can cause strange, bad and vivid dreams and difficulty sleeping. Taking hydrochloronoquine can also cause your heart to race, trigger headache, fainting, severe dizziness, nausea, a slow heart rate or weak pulse, muscle weakness, numbness and tingly, anxiety and irritability and low blood counts.
On the heels of Trump's announcement, stocks of Plaquenil, the brand-name form of hydroxychloroquine, have been depleted, leaving lupus patients in need of the drug without it. Still, with the death toll of coronavirus nearing in the US, even a drug with significant side effects would be cause for hope in the battle against coronavirus, for which there are currently no proven treatments.
Because it is already on the market and FDA approved for other uses, hydroxychloroquine can be more easily used off-label, so long as patients qualify to receive it under the Compassionate Use Act. That may mean prescriptions of the drug will only be approved for use in the most severely ill patients, although Hahn did not specify the criteria for prescribing hydroxoychloroquine to coronavirus patients. It could be months before the drug is widely distributed, if the data the slowly trickles in on the select patients approved to be treated with it under Compassionate Use and clinical trials suggest that it is safe and effective.
Trump continued to hail the expediency of the FDA's approval of the hydroxychloroquine for compassionate use. Governor Cuomo wants to be first in line,' he said. New York is also beginning trials of an older therapy: the use of antibody-rich blood plasma taken from recovered COVID patients to treat those who are still sick. The FDA approved broader use of the therapy for critically ill patients in the US, marking the first federally approved 'treatment,' for the virus in the nation.
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Coronavirus UK: Potentially effective malaria drug running out
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